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HOME»  院長の豆知識»  院長の豆知識»  高齢患者診療における抗RANKL抗体による積極的骨粗鬆症治療導入による転倒時骨折予防効果の検討(院内統計)

高齢患者診療における抗RANKL抗体による積極的骨粗鬆症治療導入による転倒時骨折予防効果の検討(院内統計)

高齢患者診療における抗RANKL抗体による積極的骨粗鬆症治療導入による転倒時骨折予防効果の検討(院内統計)


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We conducted a study to investigate the time course changes in bone metabolic markers after the administration of anti-receptor activator of nuclear factor-kappa β ligand (RANKL) antibody and prevention to bone fracture among aged osteoporotic patients. Anti-RANKL antibody is expected to provide an improvement in those with a bone metabolism disorder. We included total 65 aged osteoporotic patients who received anti-RANKL antibody and bisphosphonate or SERM (BP/SERM) treatment, 31 vs 34 respectively. To determine the time course changes in the bone metabolic markers, we measured the serum tartrate-resistant acid phosphatase 5b (TRACP 5b; a bone resorption marker) and the serum lower undercaboxylated osteocalcin (ucOC; a bone matrix related marker) levels prior to and about 1 year after administrating anti-RANKL antibody. To evaluable drug compliance, we assessed the dropout rate during treatment and at about 1 year after treatment. The average TRACP 5b and ucOC level significantly decreased 451.3 mU/dl before treatment to 142.6 mU/dl(p<0.001), 7.71 ng/ml before treatment to 1.26 ng/ml (p<0.001) respectively, at after treatment.
The bone fracture occurred for only at the time of the fall down. Number of fall down occurred in anti-RANKL antibody group and BP/SERM group was 16 vs 15 respectively, and there was not significant difference. But the number of bone fractures each the anti-RANKL antibody group and BP/SERM group was significantly difference (odds ratio 0.015).
Our study suggests that anti-RANKL antibody is very safety treatment, and suppresses bone resorption and maintains bone formation. In addition, prevention to bone fracture complication in aged patient having easy fall down.

2019-02-25 11:27:33

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